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What is Rick Simpson Oil (RSO)?
Rick Simpson Oil (RSO) is a highly concentrated, full-spectrum cannabis extract known for its exceptionally high THC content, typically ranging from 60-90%. Named after Canadian medical cannabis activist Rick Simpson, who popularized its use in the early 2000s.
Unlike other cannabis oils, RSO is made using the entire cannabis plant, preserving all cannabinoids, terpenes, and flavonoids for what is known as the "entourage effect" - the synergistic interaction of all cannabis compounds working together.
RSO appears as a thick, dark oil with a tar-like consistency. It's typically sold in syringes for precise dosing and is most commonly taken orally or sublingually.
60-90%
Typical THC Content
Full Spectrum
Whole Plant Extract

The History of RSO
In 2003, Rick Simpson, a Canadian engineer, developed skin cancer. After reading about a 1975 study showing THC could kill cancer cells in mice, Simpson decided to create his own concentrated cannabis oil.
Simpson applied the oil topically to his cancerous spots and covered them with bandages. After four days, he claims the cancerous growths were gone. This experience led him to produce and share his oil with others in need.
Despite legal challenges, Simpson continued advocating for cannabis oil and shared his extraction method freely. His documentary "Run from the Cure" (2008) brought international attention to RSO and its potential applications.
Today, RSO is one of the most recognized cannabis extracts worldwide, though research continues to evolve on its applications and efficacy.
RSO Benefits & Uses
People use RSO for various wellness purposes. Here are the most common reported benefits.
Pain Relief
RSO's high THC content provides powerful analgesic effects for chronic pain conditions.
Sleep Support
The sedating properties of RSO help promote deeper, more restful sleep.
Appetite Stimulation
Helps increase appetite for those experiencing loss of appetite from various conditions.
Nausea Relief
Effective for reducing nausea and vomiting associated with treatments or conditions.
Anxiety & Stress
May help reduce anxiety and stress when used in appropriate doses.
Inflammation
The cannabinoids in RSO have anti-inflammatory properties that may help reduce inflammation.
Medical Disclaimer
RSO is not FDA-approved and these statements have not been evaluated by the FDA. RSO is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a healthcare professional before starting any new supplement regimen.
RSO Dosing Protocol
The traditional Rick Simpson protocol spans 90 days, gradually increasing to consume 60 grams of RSO. Always start low and increase slowly.
| Week | Daily Dose | Approx. Total | Notes |
|---|---|---|---|
| Week 1 | 3 doses of 1/4 rice grain | ~0.75mg THC | Start extremely small. Take doses every 8 hours. |
| Week 2 | 3 doses of 1/2 rice grain | ~1.5mg THC | Double your dose if week 1 was well tolerated. |
| Week 3 | 3 doses of 1 rice grain | ~3mg THC | Continue doubling every 3-4 days as tolerated. |
| Week 4 | 3 doses increasing | ~6-12mg THC | Your body is building tolerance. Increase steadily. |
| Week 5-8 | Gradual increase | ~50-100mg THC | Work toward your therapeutic target dose. |
| Week 9-12 | Full protocol dose | Up to 1g RSO/day | Traditional protocol: 60g over 90 days = ~1g/day at peak. |
Start Low
Begin with a dose the size of a half grain of rice. This is roughly 1/4 of a drop from a syringe.
Go Slow
Double your dose every 3-4 days only if the current dose is well tolerated. Never rush the process.
Listen to Your Body
Everyone responds differently. If you experience discomfort, reduce your dose and increase more gradually.
How to Use RSO
There are several ways to consume RSO, each with its own benefits and considerations.
Place RSO on a small piece of food (bread, fruit, cracker) and swallow. Effects take 1-2 hours to onset but last 6-8 hours.
Pros
- Longest lasting effects
- Easy to dose
- Discrete
Cons
- Slower onset
- Passes through liver (stronger effect)
Place RSO under the tongue and hold for 60-90 seconds before swallowing. Faster absorption through mucous membranes.
Pros
- Faster onset (15-45 min)
- Bypasses first-pass metabolism
- More predictable effects
Cons
- Strong taste
- May irritate mouth
Apply RSO directly to the skin for localized relief. Mix with coconut oil for easier application.
Pros
- No psychoactive effects
- Targeted relief
- Good for skin conditions
Cons
- Limited to local effects
- May stain skin temporarily
Fill empty capsules with RSO for measured doses. Eliminates taste and allows precise dosing.
Pros
- No taste
- Precise dosing
- Convenient for travel
Cons
- Requires prep work
- Slower onset like oral method
Potential Side Effects
RSO is highly potent. Understanding potential side effects helps you use it safely.
Storage & Shelf Life
Proper storage ensures your RSO maintains its potency and quality over time. Here are the key guidelines for storing your RSO:
- Cool & Dark: Store in a cool, dark place away from direct sunlight. Heat and light degrade cannabinoids.
- Refrigeration: For long-term storage (6+ months), refrigerate RSO to extend shelf life to 1+ years.
- Airtight: Keep the syringe capped when not in use to prevent oxidation and contamination.
- Room Temperature: If using frequently, room temperature storage is fine for up to 6 months.
Quick Storage Tips
Temperature
Below 70F (21C) ideal
Room Temp Shelf Life
Up to 6 months
Refrigerated Shelf Life
1+ years
Frequently Asked Questions
Common questions about RSO answered.
How long does RSO stay in your system?
RSO can be detected in urine for 3-30 days depending on frequency of use. Heavy users may test positive for up to 90 days in hair tests. Single use typically clears in 3-10 days.
Can I drive after taking RSO?
No. RSO causes significant impairment. Do not drive, operate heavy machinery, or perform tasks requiring full attention for at least 8-12 hours after taking RSO, or longer if you still feel effects.
What if I take too much RSO?
While uncomfortable, a cannabis overdose is not life-threatening. Find a calm, safe space. Stay hydrated. Try black pepper or CBD to counteract effects. Sleep it off. Effects will pass within several hours.
Can I mix RSO with medications?
RSO may interact with certain medications, especially those metabolized by the liver. Always consult with a healthcare provider before combining RSO with prescription medications.
How should I store RSO?
Store RSO in a cool, dark place. Refrigeration extends shelf life to 1+ years. Keep the syringe capped and away from direct light. At room temperature, use within 6 months.
Is RSO legal?
RSO legality varies by location. It is legal in states/countries with legal medical or recreational cannabis programs. Always verify your local laws before purchasing or possessing RSO.
What's the difference between RSO and CBD oil?
RSO is high-THC (60-90%) and psychoactive. CBD oil contains little to no THC and is not psychoactive. RSO is a full-spectrum extract while many CBD oils are isolates or broad-spectrum.
How do I know my RSO is high quality?
Look for third-party lab testing (COA), reputable source, proper packaging, and verified cannabinoid content. Quality RSO should be dark, thick, and have a strong cannabis aroma.
Continue Your RSO Oil Research
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